Regulation of laminin and COUP-TF expression in extraembryonic endodermal cells
نویسندگان
چکیده
Laminin expression and the subsequent deposition of a basement membrane by primitive endoderm cells is necessary for early mammalian development. We demonstrate that the transcription factors COUP-TF I and II are up-regulated in primitive endoderm cells faster than LAMB1 and LAMC1, and that either COUP-TF is sufficient to induce expression of these laminin genes.
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 101 شماره
صفحات -
تاریخ انتشار 2001